Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine

Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine

Abstract Background Mycobacterium bovis bacillus Calmette-Guérin (M. bovis BCG) is the only vaccine available against tuberculosis (TB). In an effort to standardize the vaccine production, three substrains, i.e. BCG Danish 1331, Tokyo 172–1 and Russia BCG-1 were established as the WHO reference stra...

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Bibliographic Details
Main Authors: Katlyn Borgers, Jheng-Yang Ou, Po-Xing Zheng, Petra Tiels, Annelies Van Hecke, Evelyn Plets, Gitte Michielsen, Nele Festjens, Nico Callewaert, Yao-Cheng Lin
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Genomics
Subjects:
Tuberculosis
Live vaccines
BCG
Next-generation sequencing
Complete genomic sequence
Genetic differences
Online Access:http://link.springer.com/article/10.1186/s12864-019-5909-5

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http://link.springer.com/article/10.1186/s12864-019-5909-5

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