NAMPT inhibition relieves intestinal inflammation by regulating macrophage activation in experimental necrotizing enterocolitis

NAMPT inhibition relieves intestinal inflammation by regulating macrophage activation in experimental necrotizing enterocolitis

Nicotinamide phosphoribosyl transferase (NAMPT) is associated with various NAD+ -consuming enzymatic reactions. The precise role in intestinal mucosal immunity in necrotizing enterocolitis (NEC) is not well defined. Here, we examined whether NAMPT inhibition by the highly specific inhibitor FK866 co...

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Bibliographic Details
Main Authors: Qianyang Liu, Kai Gao, Xionghui Ding, Dandan Mo, Hongjie Guo, Bailin Chen, Bingshan Xia, Cuilian Ye, Gongli Chen, Chunbao Guo
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
NEC
NAMPT
NAD+
FK866
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223008028

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223008028

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