Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity

Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity

Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the colon improves glucose metabolism.

Bibliographic Details
Main Authors: Theresa V. Rohm, Lena Keller, Angela J. T. Bosch, Shefaa AlAsfoor, Zora Baumann, Amandine Thomas, Sophia J. Wiedemann, Laura Steiger, Elise Dalmas, Josua Wehner, Leila Rachid, Catherine Mooser, Bahtiyar Yilmaz, Nerea Fernandez Trigo, Annaise J. Jauch, Stephan Wueest, Daniel Konrad, Sandrine Henri, Jan H. Niess, Petr Hruz, Stephanie C. Ganal-Vonarburg, Julien Roux, Daniel T. Meier, Claudia Cavelti-Weder
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03305-z

Internet

https://doi.org/10.1038/s42003-022-03305-z

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