Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein

Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein

Abstract Parkinson’s disease (PD) presents the selective loss of A9 dopaminergic (DA) neurons of Substantia Nigra pars compacta (SNpc) and the presence of intracellular aggregates called Lewy bodies. α-synuclein (α-syn) species truncated at the carboxy-terminal (C-terminal) accumulate in pathologica...

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Bibliographic Details
Main Authors: Chiara Santulli, Carlotta Bon, Elena De Cecco, Marta Codrich, Joanna Narkiewicz, Pietro Parisse, Fabio Perissinotto, Claudio Santoro, Francesca Persichetti, Giuseppe Legname, Stefano Espinoza, Stefano Gustincich
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05489-y

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https://doi.org/10.1038/s41419-022-05489-y

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