Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads

ABSTRACTThe voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactivating mutant of rat KV1.2-KV2.1 paddle chimera (KVChi...

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Bibliographic Details
Main Authors: K. George Chandy, Karoline Sanches, Raymond S. Norton
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Channels
Subjects:
Voltage-gated potassium channel
cryogenic electron microscopy
peptide toxin
molecular modeling and docking
T cells
autoimmune diseases
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2023.2253104

Internet

https://www.tandfonline.com/doi/10.1080/19336950.2023.2253104

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