Metformin blocks MYC protein synthesis in colorectal cancer via mTOR‐4EBP‐eIF4E and MNK1‐eIF4G‐eIF4E signaling

Metformin blocks MYC protein synthesis in colorectal cancer via mTOR‐4EBP‐eIF4E and MNK1‐eIF4G‐eIF4E signaling

The antidiabetic drug metformin has been associated with reduced colorectal cancer (CRC) risk and improved prognosis of CRC patients. However, the detailed mechanisms underlying such beneficial effects remain unknown. In this study, we aimed to evaluate metformin activity in CRC models and unveil th...

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Bibliographic Details
Main Authors: Peng Shen, Lucas C. Reineke, Erik Knutsen, Meng Chen, Martin Pichler, Hui Ling, George A. Calin
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:Molecular Oncology
Subjects:
cell cycle
colorectal cancer
metformin
mTOR
MYC
protein synthesis
Online Access:https://doi.org/10.1002/1878-0261.12384

Internet

https://doi.org/10.1002/1878-0261.12384

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