Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood

Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood

Abstract The objective of this study was to evaluate whether juvenile fluoxetine (FLX) exposure induces long-term changes in baseline responses to anxiety-inducing environments, and if so, whether its re-exposure in adulthood would ameliorate this anxiety-like phenotype. An additional goal was to as...

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Bibliographic Details
Main Authors: Francisco J. Flores-Ramirez, Anapaula Themann, Jorge A. Sierra-Fonseca, Israel Garcia-Carachure, Samuel A. Castillo, Minerva Rodriguez, Omar Lira, Joshua Preciado-Piña, Brandon L. Warren, Alfred J. Robison, Sergio D. Iñiguez
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-87378-6

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https://doi.org/10.1038/s41598-021-87378-6

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