Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity

Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity

Summary: SARS-CoV-2 infection in children typically results in asymptomatic or mild disease. There is a paucity of studies on SARS-CoV-2 antiviral immunity in African children. We investigated SARS-CoV-2-specific T cell responses in 71 unvaccinated asymptomatic South African children who were seropo...

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Bibliographic Details
Main Authors: Ntombi Benede, Marius B. Tincho, Avril Walters, Vennesa Subbiah, Amkele Ngomti, Richard Baguma, Claire Butters, Lina Hahnle, Mathilda Mennen, Sango Skelem, Marguerite Adriaanse, Heidi Facey-Thomas, Christiaan Scott, Jonathan Day, Timothy F. Spracklen, Strauss van Graan, Sashkia R. Balla, Thandeka Moyo-Gwete, Penny L. Moore, Rae MacGinty, Maresa Botha, Lesley Workman, Marina Johnson, David Goldblatt, Heather J. Zar, Ntobeko A.B. Ntusi, Liesl Zühlke, Kate Webb, Catherine Riou, Wendy A. Burgers, Roanne S. Keeton
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Immunology
Immune response
Components of the immune system
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223028055

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http://www.sciencedirect.com/science/article/pii/S2589004223028055

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