Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

Abstract Background Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharmacologic action of metformin. However, epigenetics in genes encoding me...

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Bibliographic Details
Main Authors: Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa D. de Mello, Emma Nilsson, Jussi Pihlajamäki, Charlotte Ling
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Clinical Epigenetics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13148-017-0400-0