Features of drug-drug interactions rivaroxaban and calcium channel blockers depending on the ABCB1 genotype (rs1045642 and rs4148738) in patients 80 years of age and older with non-valvular atrial fibrillation

Features of drug-drug interactions rivaroxaban and calcium channel blockers depending on the ABCB1 genotype (rs1045642 and rs4148738) in patients 80 years of age and older with non-valvular atrial fibrillation

Background. The use of P-glycoprotein (P-gp) inhibitors and carriage of certain ABCB1 polymorphisms can lead to increased concentrations of rivaroxaban and the development of bleeding.The aim of the study. To study the features of drug-drug interactions (DDI) of rivaroxaban in patients over 80 years...

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Bibliographic Details
Main Authors: D. A. Sychev, K. B. Mirzaev, M. S. Cherniaeva, N. V. Shakhgildyan, Sh. P. Abdullaev, N. P. Denisenko, Zh. A. Sozaeva, A. A. Kachanova, V. R. Shastina, S. V. Gorbatenkova
Format: Article
Language:Russian
Published: Scientific Сentre for Family Health and Human Reproduction Problems 2024-01-01
Series:Acta Biomedica Scientifica
Subjects:
drug-drug interactions
rivaroxaban
verapamil
abcb1 (rs1045642 and rs4148738)
therapeutic drug monitoring
older patients
Online Access:https://www.actabiomedica.ru/jour/article/view/4493

Internet

https://www.actabiomedica.ru/jour/article/view/4493

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