Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA

Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA

ABSTRACT The formation of multimerized protein assemblies has emerged as a core component of immune signal amplification, yet the biochemical basis of this phenomenon remains unclear for many mammalian proteins within host defense pathways. The interferon-inducible protein 16 (IFI16) is a viral DNA...

Full description

Bibliographic Details
Main Authors: Krystal K. Lum, Timothy R. Howard, Catherina Pan, Ileana M. Cristea
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
IFI16
herpesvirus
innate immunity
mass spectrometry
oligomerization
proteomics
Online Access:https://journals.asm.org/doi/10.1128/mBio.01428-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01428-19

Similar Items