Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system
Refractory and relapsed leukemia is a major problem during cancer therapy, which is due to the aberrant activation of Wnt/β-catenin signaling pathway. Activation of this pathway is promoted by wingless (Wnt) proteins and induces co-activator β-catenin binding to lymphoid enhancer factor (LEF)/T-cell...
| Główni autorzy: | , , , , , , , |
|---|---|
| Format: | Artykuł |
| Język: | English |
| Wydane: |
Associação Brasileira de Divulgação Científica
2010-10-01
|
| Seria: | Brazilian Journal of Medical and Biological Research |
| Hasła przedmiotowe: | |
| Dostęp online: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000003&lng=en&tlng=en |