Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system
Refractory and relapsed leukemia is a major problem during cancer therapy, which is due to the aberrant activation of Wnt/β-catenin signaling pathway. Activation of this pathway is promoted by wingless (Wnt) proteins and induces co-activator β-catenin binding to lymphoid enhancer factor (LEF)/T-cell...
| Үндсэн зохиолчид: | , , , , , , , |
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| Формат: | Өгүүллэг |
| Хэл сонгох: | English |
| Хэвлэсэн: |
Associação Brasileira de Divulgação Científica
2010-10-01
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| Цуврал: | Brazilian Journal of Medical and Biological Research |
| Нөхцлүүд: | |
| Онлайн хандалт: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000003&lng=en&tlng=en |