Molecular mechanisms, off‐target activities, and clinical potentials of genome editing systems

Abstract Methodologies of genome editing are rapidly developing with the improvement of gene science and technology, mechanism‐based understanding, and urgent needs. In addition to the specificity and efficiency of on‐target sites, one of the most important issues is to find and avoid off‐targets be...

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Bibliographic Details
Main Authors: Nannan Zheng, Liyang Li, Xiangdong Wang
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Clinical and Translational Medicine
Subjects:
Online Access:https://doi.org/10.1002/ctm2.34