Dynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy

Dynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy

ObjectiveHigh activity of Indoleamine 2,3-dioxygenase1 (IDO1) in lung cancer patients converts tryptophan (Trp), which is the essential amino acid for T-cell metabolism, to kynurenine (Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamics of IDO1 activity in st...

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Bibliographic Details
Main Authors: Linfang Wu, Daquan Wang, Yanhua Chen, Mingmin Qian, Xin Xu, Tao Zhang, Nan Bi, Luhua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
radiotherapy
immune suppression
non-small cell lung cancer (NSCLC)
radio-resistance
indoleamine 2,3-dioxygenase (IDO)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.906815/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.906815/full

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