SCN5A Genetic Polymorphisms Associated With Increased Defibrillator Shocks in Brugada Syndrome

SCN5A Genetic Polymorphisms Associated With Increased Defibrillator Shocks in Brugada Syndrome

BackgroundBrugada syndrome (BrS) is an inherited primary arrhythmia disorder leading to sudden cardiac arrest. SCN5A, encoding the α‐subunit of the cardiac sodium channel (Nav1.5), is the most common pathogenic gene of BrS. An implantable cardioverter defibrillator (ICD) is the standard treatment fo...

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Bibliographic Details
Main Authors: Pattarapong Makarawate, Narumol Chaosuwannakit, Suda Vannaprasaht, Dujdao Sahasthas, Seok Hwee Koo, Edmund Jon Deoon Lee, Wichittra Tassaneeyakul, Hector Barajas‐Martinez, Dan Hu, Kittisak Sawanyawisuth
Format: Article
Language:English
Published: Wiley 2017-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
appropriate implantable cardioverter defibrillator shock therapy
Brugada syndrome
genetics
implantable cardioverter defibrillator
SCN5A R1193Q
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.005009

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https://www.ahajournals.org/doi/10.1161/JAHA.116.005009

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