Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration

Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration

Efforts in discovering new and effective neurotherapeutics are made daily, although most fail to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous solubility, limited permeability through biological membranes, and the hepatic first-pass metabolism. Neverth...

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Bibliographic Details
Main Authors: Sara Meirinho, Márcio Rodrigues, Adriana O. Santos, Amílcar Falcão, Gilberto Alves
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
bioavailability
brain
intranasal
neurotherapeutics
self-emulsifying drug delivery systems
Online Access:https://www.mdpi.com/1999-4923/14/7/1487

Internet

https://www.mdpi.com/1999-4923/14/7/1487

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