Assessing the therapeutic response of tumors to hypoxia-targeted prodrugs with an in silico approach

Tumor hypoxia is commonly recognized as a condition stimulating the progress of the aggressive phenotype of tumor cells. Hypoxic tumor cells inhibit the delivery of cytotoxic drugs, causing hypoxic areas to receive insufficient amounts of anticancer agents, which results in adverse treatment respons...

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Bibliographic Details
Main Authors: Defne Yilmaz, Mert Tuzer, Mehmet Burcin Unlu
Format: Article
Language:English
Published: AIMS Press 2022-08-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2022511?viewType=HTML