Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [<sup>18</sup>F]FAZA PET <i>In Vivo</i>

Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [<sup>18</sup>F]FAZA PET <i>In Vivo</i>

Tumors lack a well-regulated vascular supply of O<sub>2</sub> and often fail to balance O<sub>2</sub> supply and demand. Net O<sub>2</sub> tension within many tumors may not only depend on O<sub>2</sub> delivery but also depend strongly on O<sub>...

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Bibliographic Details
Main Authors: Seth T. Gammon, Federica Pisaneschi, Madhavi L. Bandi, Melinda G. Smith, Yuting Sun, Yi Rao, Florian Muller, Franklin Wong, John De Groot, Jeffrey Ackroyd, Osama Mawlawi, Michael A. Davies, Y.N. Vashisht Gopal, M. Emilia Di Francesco, Joseph R. Marszalek, Mark Dewhirst, David Piwnica-Worms
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
hypoxia
[18f]faza
pet
iacs-010759
mitochondrial complex i
metabolism
pharmacodynamics
oxidative phosphorylation
collateral lethality
Online Access:https://www.mdpi.com/2073-4409/8/12/1487

Internet

https://www.mdpi.com/2073-4409/8/12/1487

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