Novel Infectivity-Enhanced Oncolytic Adenovirus with a Capsid-Incorporated Dual-Imaging Moiety for Monitoring Virotherapy in Ovarian Cancer

Novel Infectivity-Enhanced Oncolytic Adenovirus with a Capsid-Incorporated Dual-Imaging Moiety for Monitoring Virotherapy in Ovarian Cancer

We sought to develop a cancer-targeted, infectivity-enhanced oncolytic adenovirus that embodies a capsid-labeling fusion for non-invasive dual-modality imaging of ovarian cancer virotherapy. A functional fusion protein composed of fluorescent and nuclear imaging tags was genetically incorporated int...

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Bibliographic Details
Main Authors: Kristopher J. Kimball, Angel A. Rivera, Kurt R. Zinn, Mert Icyuz, Vaibhav Saini, Jing Li, Zeng B. Zhu, Gene P. Siegal, Joanne T. Douglas, David T. Curiel, Ronald D. Alvarez, Anton V. Borovjagin
Format: Article
Language:English
Published: SAGE Publications 2009-09-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2009.00025

Internet

https://doi.org/10.2310/7290.2009.00025

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