Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways

Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways

In recent years, small intestine as a key target in the treatment of Inflammatory bowel disease caused by NSAIDs has become a hot topic. Sanguinarine (SA) is one of the main alkaloids in the Macleaya cordata extracts with strong pharmacological activity of anti-tumor, anti-inflammation and anti-oxid...

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Bibliographic Details
Main Authors: Xiu-lian Lin, Ya-ning Shi, Yu-ling Cao, Xi Tan, Ya-ling Zeng, Shi-teng Luo, Ya-mei Li, Li Qin, Bo-hou Xia, Rong-geng Fu, Li-mei Lin, Kai Li, Deliang Cao, Jian-guo Zeng, Duan-fang Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
sanguinarine
small intestine injury
indomethacin
Nrf2/NF-κB pathways
rats
IEC-6 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.960140/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.960140/full

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