The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anaesthesia (PRETREAT): clinical trial protocol and considerations

The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anaesthesia (PRETREAT): clinical trial protocol and considerations

Background: Intraoperative hypotension has been extensively studied for its association with adverse outcomes. However, small sample sizes and methodological issues limit the causal inference that can be drawn. Methods: In this multicentre, adaptive, randomised controlled trial, we will include 5000...

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Bibliographic Details
Main Authors: Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann, Denise P. Veelo, Teus H. Kappen, Eline de Klerk, Lisette Vernooij, Luuk C. Otterspoor, Geert-Jan E. Cromheecke, Marlous Huijzer, Jannie Witziers, Lotte E. Terwindt, Tim Bastiaanse, Rogier V. Immink, Magnus Strypet, Niek H. Sperna Weiland, Marije Wijnberge, Marc G.H. Besselink, Lisette M. Vernooij, Yvonne C. Janmaat, Annemarie Akkermans
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:BJA Open
Subjects:
blood pressure
intraoperative hypotension
myocardial injury
organ injury
renal injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2772609624000066

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http://www.sciencedirect.com/science/article/pii/S2772609624000066

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