Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption.

Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption.

Damaged acinar cells play a passive role in activating pancreatic stellate cells (PSCs) via recruitment of immune cells that subsequently activate PSCs. However, whether acinar cells directly contribute to PSC activation is unknown. Here, we report that the Hippo pathway, a well-known regulator of p...

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Bibliographic Details
Main Authors: Jun Liu, Ming Gao, Michael Nipper, Janice Deng, Francis E Sharkey, Randy L Johnson, Howard C Crawford, Yidong Chen, Pei Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-09-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000418

Internet

https://doi.org/10.1371/journal.pbio.3000418

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