Metabolic engineering for the biosynthesis of bis-indolylquinone terrequinone A in Escherichia coli from L-tryptophan and prenol

Metabolic engineering for the biosynthesis of bis-indolylquinone terrequinone A in Escherichia coli from L-tryptophan and prenol

Abstract Background Terrequinone A is a bis-indolylquinone natural product with antitumor activity. Due to its unique asymmetric quinone core structure and multiple functional groups, biosynthesis is more efficient and environmentally friendly than traditional chemical synthesis. Currently, most bis...

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Bibliographic Details
Main Authors: Lijuan Wang, Yongdong Deng, Rihe Peng, Jianjie Gao, Zhenjun Li, Wenhui Zhang, Jing Xu, Bo Wang, Yu Wang, Hongjuan Han, Xiaoyan Fu, Yongsheng Tian, Quanhong Yao
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
Biosynthesis
Bis-indolylquinone
Terrequinone A
Dimethylallyl diphosphate (DMAPP)
L-tryptophan (L-Trp)
Escherichia coli
Online Access:https://doi.org/10.1186/s13068-023-02284-5

Internet

https://doi.org/10.1186/s13068-023-02284-5

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