Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection

Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection

ABSTRACT Due to the limitations of effective treatments, avian influenza A H5N1 virus is the most lethal influenza virus strain that causes severe acute lung injury (ALI). To develop effective drugs ameliorating H5N1-induced ALI, we explore an RNA interference (RNAi) screening method to monitor chan...

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Bibliographic Details
Main Authors: Cong Zhang, Yuqing Zhang, Yuhao Qin, Qingchao Zhang, Qiang Liu, Daozhen Shang, Huijun Lu, Xiao Li, Congzhao Zhou, Fengming Huang, Ningyi Jin, Chengyu Jiang
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSystems
Subjects:
H5N1
lung injury
ifenprodil
flavopiridol
drug repurposing
genomewide RNAi
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00431-19

Internet

https://journals.asm.org/doi/10.1128/mSystems.00431-19

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