Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption

Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption

Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease ca...

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Bibliographic Details
Main Authors: Casper Larsen, Anders Etzerodt, Mette Madsen, Karsten Skjødt, Søren Kragh Moestrup, Christian Brix Folsted Andersen
Format: Article
Language:English
Published: Nature Portfolio 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07468-4

Internet

https://doi.org/10.1038/s41467-018-07468-4

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