Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lung Axis

Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lung Axis

BackgroundIn extremely premature infants, postnatal growth restriction (PNGR) is common and increases the risk of developing bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). Mechanisms by which poor nutrition impacts lung development are unknown, but alterations in the gut microbiot...

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Bibliographic Details
Main Authors: Stephen Wedgwood, Kimberly Gerard, Katrina Halloran, Ashley Hanhauser, Sveva Monacelli, Cris Warford, Phung N. Thai, Nipavan Chiamvimonvat, Satyan Lakshminrusimha, Robin H. Steinhorn, Mark A. Underwood
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
intestinal dysbiosis
TLR4
pulmonary hypertension
bronchopulmonary dysplasia
premature infant
Enterobacteriaceae
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00357/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00357/full

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