Engineering siRNA-loaded and RGDfC-targeted selenium nanoparticles for highly efficient silencing of DCBLD2 gene for colorectal cancer treatment

Engineering siRNA-loaded and RGDfC-targeted selenium nanoparticles for highly efficient silencing of DCBLD2 gene for colorectal cancer treatment

Abstract Effective and safe delivery of small interfering RNA (siRNA) by nanomaterials to cancer cells is one of the main challenges in cancer treatment. In this study, we constructed the selenium nanoparticles conjugated with RGDfC (one tumor-targeted polypeptide) to prepare a biocompatible gene ve...

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Bibliographic Details
Main Authors: Hongli Huang, Hanqing Chen, Diwen Shou, Ying Quan, Jiemin Cheng, Huiting Chen, Gang Ning, Yongqiang Li, Yu Xia, Yongjian Zhou
Format: Article
Language:English
Published: Springer 2023-07-01
Series:Discover Nano
Subjects:
Selenium nanoparticles
Small interfering RNA
Endocytosis
Colorectal cancer
Combination therapy
Online Access:https://doi.org/10.1186/s11671-023-03870-0

Internet

https://doi.org/10.1186/s11671-023-03870-0

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