Engineering siRNA-loaded and RGDfC-targeted selenium nanoparticles for highly efficient silencing of DCBLD2 gene for colorectal cancer treatment
Abstract Effective and safe delivery of small interfering RNA (siRNA) by nanomaterials to cancer cells is one of the main challenges in cancer treatment. In this study, we constructed the selenium nanoparticles conjugated with RGDfC (one tumor-targeted polypeptide) to prepare a biocompatible gene ve...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Springer
2023-07-01
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Series: | Discover Nano |
Subjects: | |
Online Access: | https://doi.org/10.1186/s11671-023-03870-0 |