Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity

Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity

Abstract Background Sepsis is characterized by a dysregulated immune response to infection. The complement system plays an important role in the host defence to pathogens. However, exaggerated complement activation might contribute to a hyperinflammatory state. The interplay between complement activ...

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Bibliographic Details
Main Authors: Aline H. de Nooijer, Antigone Kotsaki, Eleftheria Kranidioti, Matthijs Kox, Peter Pickkers, Erik J. M. Toonen, Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Critical Care
Subjects:
Sepsis
Inflammation
Complement
Septic shock
Mortality
Online Access:https://doi.org/10.1186/s13054-023-04344-6

Internet

https://doi.org/10.1186/s13054-023-04344-6

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