Airway Exposure to Polyethyleneimine Nanoparticles Induces Type 2 Immunity by a Mechanism Involving Oxidative Stress and ATP Release

Airway Exposure to Polyethyleneimine Nanoparticles Induces Type 2 Immunity by a Mechanism Involving Oxidative Stress and ATP Release

Polyethyleneimine (PEI) induced immune responses were investigated in human bronchial epithelial (hBE) cells and mice. PEI rapidly induced ATP release from hBE cells and pretreatment with glutathione (GSH) blocked the response. PEI activated two conductive pathways, VDAC-1 and pannexin 1, which comp...

Full description

Bibliographic Details
Main Authors: Yotesawee Srisomboon, Noriyuki Ohkura, Koji Iijima, Takao Kobayashi, Peter J. Maniak, Hirohito Kita, Scott M. O’Grady
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
allergic inflammation
purinergic signaling
IL-33
Th2 cytokines
intracellular Ca<sup>2+</sup>
Online Access:https://www.mdpi.com/1422-0067/22/16/9071

Internet

https://www.mdpi.com/1422-0067/22/16/9071

Similar Items