Efficient Synthesis with Green Chemistry Approach of Novel Pharmacophores of Imidazole-Based Hybrids for Tumor Treatment: Mechanistic Insights from In Situ to In Silico

Efficient Synthesis with Green Chemistry Approach of Novel Pharmacophores of Imidazole-Based Hybrids for Tumor Treatment: Mechanistic Insights from In Situ to In Silico

Imidazole-based pyrimidine hybrids are considered a remarkable class of compounds in pharmaceutical chemistry. Here, we report the anticancer bioactivities of eleven imidazole-based pyrimidine hybrids (<b>1</b>–<b>11</b>) that specifically target cytosolic carbonic anhydrase...

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Bibliographic Details
Main Authors: Majid Khan, Syed Raza Shah, Faizullah Khan, Sobia Ahsan Halim, Shaikh Mizanoor Rahman, Mohammad Khalid, Ajmal Khan, Ahmed Al-Harrasi
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
imidazole-based hybrids with hydroxyethyl and pyrimidine
anticancer
mechanistic studies
cytotoxicity
in silico molecular docking
Online Access:https://www.mdpi.com/2072-6694/14/20/5079

Internet

https://www.mdpi.com/2072-6694/14/20/5079

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