P1245 Polymorphic Variants of HSD3B1 Gene Confer Different Outcome in Specific Subgroups of Patients Infected With SARS-CoV-2

P1245 Polymorphic Variants of HSD3B1 Gene Confer Different Outcome in Specific Subgroups of Patients Infected With SARS-CoV-2

Introduction: Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the androgen receptor (AR), through ACE2 receptor and TMPRSS2, to enter nasal and upper airways epithelial cells. Genetic analyses revealed that HSD3B1 P1245C polymorphic variant increases dihydrotestosterone production and up...

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Bibliographic Details
Main Authors: Samantha Epistolio, Giulia Ramelli, Margaret Ottaviano, Emanuele Crupi, Laura Marandino, Maira Biggiogero, Pier Andrea Maida, Lorenzo Ruinelli, Ursula Vogl, Dylan Mangan, Mariarosa Pascale, Marco Cantù, Alessandro Ceschi, Enos Bernasconi, Luca Mazzucchelli, Carlo Catapano, Andrea Alimonti, Christian Garzoni, Silke Gillessen Sommer, Federico Mattia Stefanini, Alessandra Franzetti-Pellanda, Milo Frattini, Ricardo Pereira Mestre
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Medicine
Subjects:
SARS-CoV-2
HSD3B1 gene polymorphism
androgen receptor
direct sequencing
Likelihood-ratio tests
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.793728/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.793728/full

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