Absence of CD11a Expression Identifies Embryonic Hematopoietic Stem Cell Precursors via Competitive Neonatal Transplantation Assay

Absence of CD11a Expression Identifies Embryonic Hematopoietic Stem Cell Precursors via Competitive Neonatal Transplantation Assay

Hematopoietic stem cells (HSCs) are defined by their self-renewal, multipotency, and bone marrow (BM) engraftment abilities. How HSCs emerge during embryonic development remains unclear, but are thought to arise from hemogenic endothelium through an intermediate precursor called “pre-HSCs.” Pre-HSCs...

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Bibliographic Details
Main Authors: Alborz Karimzadeh, Erika S. Varady, Vanessa M. Scarfone, Connie Chao, Karin Grathwohl, Pauline U. Nguyen, Yasamine Ghorbanian, Irving L. Weissman, Thomas Serwold, Matthew A. Inlay
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
embryo
flow cytometry
hematopoietic stem cell (HSC)
hematopoietic stem cell transplantation
neonatal transplantation
embryonic hematopoiesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.734176/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.734176/full

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