OnTAD: hierarchical domain structure reveals the divergence of activity among TADs and boundaries
Abstract The spatial organization of chromatin in the nucleus has been implicated in regulating gene expression. Maps of high-frequency interactions between different segments of chromatin have revealed topologically associating domains (TADs), within which most of the regulatory interactions are th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-12-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-019-1893-y |