Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection

Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection

Mice reconstituted with human immune systems are instrumental in the investigation of HIV-1 pathogenesis and therapeutics. Natural killer (NK) cells have long been recognized as a key mediator of innate anti-HIV responses. However, established humanized mouse models do not support robust human NK ce...

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Bibliographic Details
Main Authors: Shawn A. Abeynaike, Tridu R. Huynh, Abeera Mehmood, Teha Kim, Kayla Frank, Kefei Gao, Cristina Zalfa, Angel Gandarilla, Leonard Shultz, Silke Paust
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
humanized mice
NSG
NK cells
IL-15
HIV-1
immunotherapy
Online Access:https://www.mdpi.com/1999-4915/15/2/365

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https://www.mdpi.com/1999-4915/15/2/365

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