Engineering the Single Domain Antibodies Targeting Receptor Binding Motifs Within the Domain III of West Nile Virus Envelope Glycoprotein

Engineering the Single Domain Antibodies Targeting Receptor Binding Motifs Within the Domain III of West Nile Virus Envelope Glycoprotein

West Nile virus (WNV) is a mosquito-borne neurotrophic flavivirus causing mild febrile illness to severe encephalitis and acute flaccid paralysis with long-term or permanent neurological disorders. Due to the absence of targeted therapy or vaccines, there is a growing need to develop effective anti-...

Full description

Bibliographic Details
Main Authors: Jana Hruškovicová, Katarína Bhide, Patrícia Petroušková, Zuzana Tkáčová, Evelína Mochnáčová, Ján Čurlík, Mangesh Bhide, Amod Kulkarni
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Microbiology
Subjects:
West Nile virus
single domain antibody
nanobodies
human brain microvascular endothelial cells
phage display
West Nile virus-like particles
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.801466/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.801466/full

Similar Items