Natural Flavonoids Quercetin and Kaempferol Targeting G2/M Cell Cycle-Related Genes and Synergize with Smac Mimetic LCL-161 to Induce Necroptosis in Cholangiocarcinoma Cells

Natural Flavonoids Quercetin and Kaempferol Targeting G2/M Cell Cycle-Related Genes and Synergize with Smac Mimetic LCL-161 to Induce Necroptosis in Cholangiocarcinoma Cells

Cholangiocarcinoma (CCA) is an aggressive cancer associated with a very poor prognosis and low survival rates, primarily due to late-stage diagnosis and low response rates to conventional chemotherapy. Therefore, there is an urgent need to identify effective therapeutic strategies that can improve p...

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Bibliographic Details
Main Authors: Thanpisit Lomphithak, Patthorn Jaikla, Apiwit Sae-Fung, Sasiprapa Sonkaew, Siriporn Jitkaew
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Nutrients
Subjects:
Cholangiocarcinoma
necroptosis
Smac mimetics
quercetin
kaempferol
Online Access:https://www.mdpi.com/2072-6643/15/14/3090

Internet

https://www.mdpi.com/2072-6643/15/14/3090

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