Construction and Characterization of Severe Fever with Thrombocytopenia Syndrome Virus with a Fluorescent Reporter for Antiviral Drug Screening

Construction and Characterization of Severe Fever with Thrombocytopenia Syndrome Virus with a Fluorescent Reporter for Antiviral Drug Screening

Severe fever with thrombocytopenia syndrome (SFTS) caused by a novel bunyavirus (SFTSV) is an emerging infectious disease with up to 30% case fatality. Currently, there are no specific antiviral drugs or vaccines for SFTS. Here, we constructed a reporter SFTSV in which the virulent factor nonstructu...

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Bibliographic Details
Main Authors: Xiao Wang, Mingyue Xu, Huanhuan Ke, Longda Ma, Liushuai Li, Jiang Li, Fei Deng, Manli Wang, Zhihong Hu, Jia Liu
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Viruses
Subjects:
severe fever with thrombocytopenia syndrome virus
fluorescent virus
NSs deletion
attenuated virulence
high-content antiviral drugs screening
Online Access:https://www.mdpi.com/1999-4915/15/5/1147

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https://www.mdpi.com/1999-4915/15/5/1147

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