Dampened Regulatory Circuitry of TEAD1/ITGA1/ITGA2 Promotes TGFβ1 Signaling to Orchestrate Prostate Cancer Progression

Dampened Regulatory Circuitry of TEAD1/ITGA1/ITGA2 Promotes TGFβ1 Signaling to Orchestrate Prostate Cancer Progression

Abstract The extracellular matrix (ECM) undergoes substantial changes during prostate cancer (PCa) progression, thereby regulating PCa growth and invasion. Herein, a meta‐analysis of multiple PCa cohorts is performed which revealed that downregulation or genomic loss of ITGA1 and ITGA2 integrin gene...

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Bibliographic Details
Main Authors: Sara P. Cruz, Qin Zhang, Raman Devarajan, Christos Paia, Binjie Luo, Kai Zhang, Saara Koivusalo, Longguang Qin, Jihan Xia, Anne Ahtikoski, Markku Vaarala, Tomasz Wenta, Gong‐Hong Wei, Aki Manninen
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
ECM
EMT
epithelium
integrin
prostate
Online Access:https://doi.org/10.1002/advs.202305547

Internet

https://doi.org/10.1002/advs.202305547

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