Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis

Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis

A hallmark of chronic kidney disease is renal fibrosis, which can result in progressive loss of kidney function. Currently, there is no effective therapy for renal fibrosis. Therefore, there is an urgent need to identify potential drug targets for renal fibrosis. In this study, we examined the effec...

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Bibliographic Details
Main Authors: Baihai Jiao, Changlong An, Melanie Tran, Hao Du, Penghua Wang, Dong Zhou, Yanlin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
fibroblasts
macrophages
extracellular matrix
renal fibrosis
STAT6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.735014/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.735014/full

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