Development of mucosal vaccine via respiratory tract based on mRNA-peptide-poloxamine nanoparticles

Development of mucosal vaccine via respiratory tract based on mRNA-peptide-poloxamine nanoparticles

Objective To design and prepare mRNA-peptide-poloxamine ternary complex (mRNA-PPTC) nanoparticles and explore their physicochemical properties, in vitro/vivo delivery efficiency, and induction of specific antibody production in immunized mice. Methods The mRNAs coding firefly luciferase (F-luc), enh...

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Bibliographic Details
Main Authors: YANG Qihua, LIU Yuheng, ZHANG Dandan, LI Chao
Format: Article
Language:zho
Published: Editorial Office of Journal of Army Medical University 2023-07-01
Series:陆军军医大学学报
Subjects:
nanoparticles
nucleic acid delivery
mrna vaccine
mucosal vaccine
Online Access:http://aammt.tmmu.edu.cn/html/202303115.htm

Internet

http://aammt.tmmu.edu.cn/html/202303115.htm

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