EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning

EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning

EDEM3 recognizes and directs misfolded proteins to the ER-associated protein degradation (ERAD) process. EDEM3 was predicted to act as lectin or as a mannosidase because of its homology with the GH47 catalytic domain of the Man1B1, but the contribution of the other regions remained unresolved. Here,...

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Bibliographic Details
Main Authors: Georgiana Manica, Simona Ghenea, Cristian V. A. Munteanu, Eliza C. Martin, Cristian Butnaru, Marius Surleac, Gabriela N. Chiritoiu, Petruta R. Alexandru, Andrei-Jose Petrescu, Stefana M. Petrescu
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
EDEM3
ERAD
NHK
tyrosinase
mass spectrometry
ER mannosidases
Online Access:https://www.mdpi.com/1422-0067/22/4/2172

Internet

https://www.mdpi.com/1422-0067/22/4/2172

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