Titanium Nanoparticles Enhance Production and Suppress Stabilin-1-Mediated Clearance of GDF-15 in Human Primary Macrophages

Titanium Nanoparticles Enhance Production and Suppress Stabilin-1-Mediated Clearance of GDF-15 in Human Primary Macrophages

Macrophages are key innate immune cells that mediate implant acceptance or rejection. Titanium implants degrade over time inside the body, which results in the release of implant wear-off particles. Titanium nanoparticles (TiNPs) favor pro-inflammatory macrophage polarization (M1) and lower toleroge...

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Bibliographic Details
Main Authors: Lina S. Silva-Bermudez, Tatyana N. Sevastyanova, Christina Schmuttermaier, Carolina De La Torre, Leonie Schumacher, Harald Klüter, Julia Kzhyshkowska
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
titanium
nanoparticle
macrophage
endocytosis
scavenger receptor
growth factor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.760577/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.760577/full

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