The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male MiceSummary

The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male MiceSummary

Background: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in North America, accounting for >30,000 deaths annually. Although somatic activating mutations in KRAS appear in 97% of PDAC patients, additional factors are required to initiate PDAC. Because mutation...

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Bibliographic Details
Main Authors: Claire C. Young, Ryan M. Baker, Christopher J. Howlett, Todd Hryciw, Joshua E. Herman, Douglas Higgs, Richard Gibbons, Howard Crawford, Arthur Brown, Christopher L. Pin
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X18301255

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http://www.sciencedirect.com/science/article/pii/S2352345X18301255

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