Optogenetic dissection of mitotic spindle positioning in vivo

Optogenetic dissection of mitotic spindle positioning in vivo

The position of the mitotic spindle determines the plane of cell cleavage, and thereby daughter cell location, size, and content. Spindle positioning is driven by dynein-mediated pulling forces exerted on astral microtubules, which requires an evolutionarily conserved complex of Gα∙GDP, GPR-1/2Pins/...

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Bibliographic Details
Main Authors: Lars-Eric Fielmich, Ruben Schmidt, Daniel J Dickinson, Bob Goldstein, Anna Akhmanova, Sander van den Heuvel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
optogenetics
mitotic spindle positioning
dynein
germline silencing
LIN-5 (NuMA)
cell division
Online Access:https://elifesciences.org/articles/38198

Internet

https://elifesciences.org/articles/38198

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