UBXN2A enhances CHIP‐mediated proteasomal degradation of oncoprotein mortalin‐2 in cancer cells

UBXN2A enhances CHIP‐mediated proteasomal degradation of oncoprotein mortalin‐2 in cancer cells

Overexpression of oncoproteins is a major cause of treatment failure using current chemotherapeutic drugs. Drug‐induced degradation of oncoproteins is feasible and can improve clinical outcomes in diverse types of cancers. Mortalin‐2 (mot‐2) is a dominant oncoprotein in several tumors, including col...

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Bibliographic Details
Main Authors: Sanam Sane, Andre Hafner, Rekha Srinivasan, Daniall Masood, John l. Slunecka, Collin J. Noldner, Alex D. Hanson, Taylor Kruisselbrink, Xuejun Wang, Yiyang Wang, Jun Yin, Khosrow Rezvani
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:Molecular Oncology
Subjects:
CHIP E3 ligase
colorectal cancer
mortalin‐2
mouse
UBXN2A
veratridine
Online Access:https://doi.org/10.1002/1878-0261.12372

Internet

https://doi.org/10.1002/1878-0261.12372

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