Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

We identify a set of common phenotypic modifiers that interact with five independent autism gene orthologs (RIMS1, CHD8, CHD2, WDFY3, ASH1L) causing a common failure of presynaptic homeostatic plasticity (PHP) in Drosophila. Heterozygous null mutations in each autism gene are demonstrated to have no...

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Bibliographic Details
Main Authors: Özgür Genç, Joon-Yong An, Richard D Fetter, Yelena Kulik, Giulia Zunino, Stephan J Sanders, Graeme W Davis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
autism
CHD8
homeostatic plasticity
neurotransmission
presynaptic
CREG
Online Access:https://elifesciences.org/articles/55775

Internet

https://elifesciences.org/articles/55775

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