Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers
We identify a set of common phenotypic modifiers that interact with five independent autism gene orthologs (RIMS1, CHD8, CHD2, WDFY3, ASH1L) causing a common failure of presynaptic homeostatic plasticity (PHP) in Drosophila. Heterozygous null mutations in each autism gene are demonstrated to have no...
Main Authors: | Özgür Genç, Joon-Yong An, Richard D Fetter, Yelena Kulik, Giulia Zunino, Stephan J Sanders, Graeme W Davis |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/55775 |
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