Probing the Effect of Bulky Lesion-Induced Replication Fork Conformational Heterogeneity Using 4-Aminobiphenyl-Modified DNA

Probing the Effect of Bulky Lesion-Induced Replication Fork Conformational Heterogeneity Using 4-Aminobiphenyl-Modified DNA

Bulky organic carcinogens are activated in vivo and subsequently react with nucleobases of cellular DNA to produce adducts. Some of these DNA adducts exist in multiple conformations that are slowly interconverted to one another. Different conformations have been implicated in different mutagenic and...

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Bibliographic Details
Main Authors: Ang Cai, Ke Bian, Fangyi Chen, Qi Tang, Rachel Carley, Deyu Li, Bongsup P. Cho
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
4-aminobiphenyl
bulky DNA lesion
conformational heterogeneity
surface plasmon resonance (SPR) binding kinetics
steady state enzyme kinetics
Klenow fragment
Online Access:https://www.mdpi.com/1420-3049/24/8/1566

Internet

https://www.mdpi.com/1420-3049/24/8/1566

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