Expression of human frataxin is regulated by transcription factors SRF and TFAP2.

Expression of human frataxin is regulated by transcription factors SRF and TFAP2.

Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by reduced expression levels of the frataxin gene (FXN) due to expansion of triplet nucleotide GAA repeats in the first intron of FXN. Augmentation of frataxin expression levels in affected Friedreich ataxia patient tissues...

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Bibliographic Details
Main Authors: Kuanyu Li, Anamika Singh, Daniel R Crooks, Xiaoman Dai, Zhuangzhuang Cong, Liang Pan, Dung Ha, Tracey A Rouault
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2924884?pdf=render

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http://europepmc.org/articles/PMC2924884?pdf=render

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